The human intestinal tract is inhabited by 10-100 trillion microbes consisting of thousands of different species that have co-evolved with the human host. This microbial community, termed the gut microbiota, has an immense capacity to affect host biology.
It is fundamental to many processes, including development of our immune system, processing of otherwise indigestible dietary polysaccharides, and production of vitamins and hormones. However, increasing evidence indicates that perturbations of the gut microbiota contribute to a range of diseases, including obesity and cardiometabolic diseases.
We take a translational approach to investigate the role of the gut microbiota in cardiometabolic diseases, focusing on diabetes, hepatic steatosis, atherosclerosis, and heart failure.
By identifying associations between gut bacteria and/or their metabolites and cardiometabolic markers in large population-based cohort studies, we generate hypotheses that could explain how the microbiota contributes to metabolic diseases.
Our hypotheses are tested using a variety of tools, including gnotobiotic mice, primary cell culture, and bioreactors to establish causality and determine the underlying molecular mechanisms.
Words describing the culture in our lab.
Our team has co-authored a large number of highly impactful original research and literature review articles.
Microbially produced imidazole propionate is associated with heart failure and mortality
Open access article online, JACC Heart Failure, April 2023
6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice
Article, Gut, February 2023
Microbiome-derived ethanol in nonalcoholic fatty liver disease
Article, Nature Medicine 10 Oct, 2022
The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease
Review article, Nat Rev Cardiol, 14 Oct 2022
Dynamics of the normal gut microbiota: A longitudinal one-year population study in Sweden
Article, Cell Host & Microbe, April 28, 2022
Our laboratory’s location, within Sahlgrenska University Hospital, provides unique opportunities to engage with clinicians and study participants and pursue basic and translational research.
To achieve our overarching aim of improving human health by targeting the gut microbiota, we have developed a research group comprising experts in microbiology, molecular biology, biochemistry, metabolomics, proteomics, epigenetics, physiology, bioinformatics, and medicine from around the world.