New paper on microbially produced imidazole propionate inhibits metformin glucose lowering
06 October 2020
Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the antidiabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionate activated p38γ.
To the paper in Cell Metabolism:
https://doi.org/10.1016/j.cmet.2020.07.012