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New paper on microbially produced imidazole propionate inhibits metformin glucose lowering

06 October 2020

Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the antidiabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionateactivated p38γ.

To the paper in Cell Metabolism:
https://doi.org/10.1016/j.cmet.2020.07.012

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