New paper on microbially produced imidazole propionate inhibits metformin glucose lowering
Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the antidiabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionateactivated p38γ.
To the paper in Cell Metabolism: