Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
Article in Nature Communications, 18 November, issue 11, 2020
Molinaro et. al show that imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology.
In summary, our data suggest that an unhealthy diet may contribute to an altered microbial community type with increased potential to metabolize dietary histidine to ImP, which in turn contributes to impaired glucose metabolism by activating MAPK signaling leading to degradation of insulin receptor substrate and inflammatory signaling. Since ImP has been observed to be increased in subjects with glucose intolerance and type 2 diabetes of several origins, personalized dietary recommendation or inhibition of urdA might be helpful for reducing circulating ImP levels.