Microbial imidazole propionate affects responses to metformin through p38γ - dependent inhibitory AMPK phosphorylation
Short article in Cell Metabolism October, Volume 32, issue 4, 2020
Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the antidiabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionateactivated p38γ.