SV EN

Microbiome-derived ethanol in nonalcoholic fatty liver disease

Article, Nature Medicine 10 Oct, 2022

Fredrik Bäckhed is one of the Co-authors of this article were it is concluded that the human gut microbiota produces large amounts of ethanol that might be clinically relevant for the pathogenesis of NAFLD. Ethanol production during an MMT should be considered as a noninvasive diagnostic approach for the detection of gut microbiota producing high levels of ethanol and NAFLD risk. In our prospective cohort, high postprandial plasma ethanol concentrations correlated particularly with high relative fecal abundance of lactic acid bacteria. Clinical trials targeting the gut microbiome have not yielded any meaningful outcome in NAFLD thus far. To what extent persistent endogenous ethanol production is causally involved in the highly complex pathogenesis of NAFLD, where a combination of environmental factors, genetic variants, obesity and disturbed lipid homeostasis interact, remains to be elucidated. Nevertheless, our findings suggest that further attention aiming to target the gut microbiota to reduce ethanol production and thereby lower additional risk for NAFLD is justified.


To the full article in Nature Medicine

 


Go back

Manage cookie settings
This website uses cookies to make our services work, and that’s why some cookies are necessary and can’t be declined. We use cookies to give you the best user experience possible. You can manage your cookies in the next session.
Cookie settings
Cookie settings
Necessary Cookies
These Cookies are necessary for our website to work and can’t be turned off. The Cookies are usually only activated when you, for example, fill out a form or create or log in to your account. They don’t track any personal information.
Performance Cookies
These Cookies help us to track the number of visitors on our webpage. They also track where our visitors came from and how they found our website. We use this information to analyze how to make our website more user-friendly for our visitors and which landing pages are most relevant for our customers. The information that we store is, for example, what pages you visit when using our website.
Marketing Cookies
We use these Cookies to analyze how we can make our advertising better. The information helps us to learn more about our visitors and makes it possible to personalize ads based on your previous use of our services.