Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes
Article, Open Access, Nature Medicine, April 2025
Type 2 diabetes (T2D) is influenced by genetic and environmental factors, including the gut microbiome. Recent research in two Swedish cohorts (n=1,167) identified over 500 blood metabolites linked to impaired glucose control, with about one-third associated with an altered gut microbiome. Metabolic disruptions in microbiome–metabolome dynamics may mediate compromised glucose homeostasis. Short-term lifestyle changes, such as diet and exercise, modulated microbiome-associated metabolites. This study suggests the microbiome–metabolome axis as a modifiable target for T2D management, with optimal benefits from lifestyle modifications.