Postdoctoral Research Fellow
My research is focused on environmental control in a number of settings, including metabolic disease, heritability, and epigenetic control during hibernation.
I am investigating the role of the gut microbiota in mediating human chromatin states, particularly at the level of histone post-translational modifications (PTMs) and how this regulation contributes to the development and progression of non-alcoholic fatty liver disease (NAFLD). During my PhD work, we showed that the microbiota can regulate global host histone PTM states in mice, but whether this relationship can occur in humans remains unknown. Additional work is focused on identifying gut microbial features that are regulated purely by environmental factors in the absence of host genetic effects, understanding the heritability of microbiota-driven chromatin states, and identifying novel histone PTMs that are regulated by the gut microbiota. I am also wrapping up a project geared toward understanding how chromatin responds to and potentially drives the mammalian hibernation cycle.