Microbiota and type 2 diabetes

Over the past 20 years, considerable effort has been directed toward clarifying how the gut microbiota is associated with obesity and cardiometabolic diseases. Obesity results from an imbalance between energy intake and energy expenditure and is a well-established risk factor for type 2 diabetes. However, not all individuals with obesity develop type 2 diabetes and additional factors are known to play a role in this disease. We and others have shown that the gut microbiota is altered in subjects with type 2 diabetes and that the microbiome may have predictive capacity for type 2 diabetes.

One major challenge in the microbiome field is to determine whether the microbiota contributes to the disease or whether the altered microbiota is simply the result of the disease itself or treatments for the disease. The following points provide evidence supporting the role of the gut microbiota in the development of type 2 diabetes.

  • We have shown that individuals with prediabetes (particularly those with impaired glucose tolerance) have an altered gut microbiota. One consistent feature of the microbiota in individuals with prediabetes/type 2 diabetes is low abundance of butyrate-producing bacteria. 
  • We have shown that diabetes phenotypes can be transferred by colonizing germ-free mice with fecal microbiota from humans with type 2 diabetes.
  • Our collaborator Max Nieuwdorp has shown that transfer of fecal microbiota from lean healthy individuals to individuals with the metabolic syndrome can improve insulin sensitivity.
  • We and others have identified a number of microbially produced metabolites (such as imidazole propionate and secondary bile acids) that are associated with type 2 diabetes.

Our major focus is to use the microbiota to improve stratification of individuals with prediabetes and type 2 diabetes and design personalized microbiome-based treatments. To achieve this goal, it is important to increase our mechanistic insight into how the gut microbiota can contribute to insulin resistance and type 2 diabetes.

"Hope for a drug against type 2 diabetes"

A film produced by Knut & Alice Wallenberg Foundation.

Manage cookie settings
This website uses cookies to make our services work, and that’s why some cookies are necessary and can’t be declined. We use cookies to give you the best user experience possible. You can manage your cookies in the next session.
Cookie settings
Cookie settings
Necessary Cookies
These Cookies are necessary for our website to work and can’t be turned off. The Cookies are usually only activated when you, for example, fill out a form or create or log in to your account. They don’t track any personal information.
Performance Cookies
These Cookies help us to track the number of visitors on our webpage. They also track where our visitors came from and how they found our website. We use this information to analyze how to make our website more user-friendly for our visitors and which landing pages are most relevant for our customers. The information that we store is, for example, what pages you visit when using our website.
Marketing Cookies
We use these Cookies to analyze how we can make our advertising better. The information helps us to learn more about our visitors and makes it possible to personalize ads based on your previous use of our services.