GLP-1 from the distal gut is dispensable for body weight and glucose regulation but slows small intestinal transit in female mice
Article, American Journal of Physiology-Endocrinology and Metabolism, January, December 2025
Previous studies have suggested that GLP-1 from the distal gut may be of importance for regulation of glucose metabolism although the contribution from ileal and colonic GLP-1 has not been separated. In this study, authored by Thomas Greiner, we established a mouse model to more specifically dissect the role of colonic GLP-1 and demonstrate that the physiological role of GLP-1 from the colon does not include the well-established metabolic functions but rather slows small intestinal transit.
To the article in the American Journal of Physiology-Endocrinology and Metabolism