Gut Microbiota Mediates SREBP-1c-Driven Hepatic Lipogenesis and Steatosis in Response to Zero-fat High-Sucrose Diet
Article, Molecular Metabolism, In Press, 7 May, 2025
Sucrose-rich diets promote hepatic de novo lipogenesis (DNL) and steatosis through interactions with the gut microbiota. However, the role of sugar-microbiota dynamics in the absence of dietary fat remains unclear. In this article, first author Mattias Bergentall with several co-authors from our lab, conclude that sucrose-microbiota interactions and SREBP-1c are required for DNL and hepatic steatosis in the absence of dietary fat. These findings provide new insights into the complex interplay between diet, gut microbiota, and metabolic regulation.
To the article in Molecular Metabolism