SV EN

Lei Geng

Postdoctoral Research Fellow

PhD

More and more research results show that gut microbiota have complex relationship with host. For the past decades,it was proved that the bacterial derived metabolites play an important role in host on nutriology,physiology,pathology,immunology as well as developmental biology.


The former work in Bäckhed lab showed that imidazole propionate, a metabolite from gut microbiota, which responsible for the metabolic diseases type 2 diabetes.

My research area in the lab is focused on the role of imidazole propionate play in host. I will explore how imidazole propionate can affect the host physiology and signaling in the intestine and the resulting effects on host metabolism. To this end I will use tissue specific knock out mice deficient in imidazole propionate signaling in the gut as well as organoids. Besides, I found a bacterial derived compound which have a function on the development of the insect gut in my former work and I want to continue explore whether this compound have same or similar phenotype on mice.

Ultimately, I would like to contribute a better understanding about the mechanism of metabolites from microbiota on the host physiology.

 

More about me

Gothenburg University

 


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