Article published in Nature Medicine
Today our paper ”Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes” was published with Open Access in Nature Medicine. First author is our former colleague Hao (Tony) Wu, now Principal Investigator at the Fudan University, China.
Type 2 diabetes (T2D) is influenced by genetic and environmental factors, including the gut microbiome. Recent research in two Swedish cohorts (n=1,167) identified over 500 blood metabolites linked to impaired glucose control, with about one-third associated with an altered gut microbiome. Metabolic disruptions in microbiome–metabolome dynamics may mediate compromised glucose homeostasis. Short-term lifestyle changes, such as diet and exercise, modulated microbiome-associated metabolites. This study suggests the microbiome–metabolome axis as a modifiable target for T2D management, with optimal benefits from lifestyle modifications.