Ashwinipriyadarshini Megur, Avee, is a visiting student from Vilnius, Lithuania, who is doing part of her Biochemistry PhD studies with us. We decided to ask her some questions about her experience in our Lab and the city of Gothenburg so far and about science in general.

How come you wanted to come to our lab?
I am currently pursuing my PhD at Vilnius University in Lithuania, focusing on the characterization of a novel probiotic strain with psychobiotic, anti-diabetic, and anti-inflammatory properties. I am nearing the completion of my studies. I wanted to do my internship in Bäckhed´s lab because of the focus on cardiometabolic syndrome, which aligns with my PhD research on diet-induced Type 2 diabetes.

What is your role in the group/main area of expertise?
I am currently exploring the impact of imidazole propionate on lung health. My research focuses on assessing the potential harmful effects of this microbial metabolite by comparing the histological and biochemical changes in mice that are fed a Western diet versus those on a chow diet. The aim of my study is to ascertain whether imidazole propionate affects lung function and contributes to adverse health effects.

What are you hoping to learn from the internship?
I look forward to mastering all the unique steps and new techniques you are using and incorporating them into my doctoral research, including animal work, meticulous evaluation of the obtained organs and an in-depth analysis of the outcomes.

Your impressions from the lab and from the city of Gothenburg, Sweden?
I absolutely love the lab. The people here are incredibly kind and supportive. They gather like a family, always ready to assist one another when faced with challenges. It feels more like a tight-knit community than simply co-workers collaborating on a project.

Gothenburg is an incredibly charming city. Just like Vilnius it has a cozy, slightly gritty atmosphere, yet it has its own distinct flair. The blend of old and new, along with scenic canals, lush parks, and beautiful architecture, creates perfect harmony between nature and urban life. Gothenburg's laid-back appeal, along with its emphasis on sustainability and culture, makes it a wonderful destination to visit or live in. Whether indulging in the fantastic culinary scene, enjoying the harbor views, or exploring the stunning green spaces, there’s a subtle beauty here that makes me feel like home, much like Vilnius, but with a touch of Scandinavian charm!

 

Anything to share about time outside the lab?
I try to find balance by engaging in activities that allow me to relax and rejuvenate. I relish time spent in nature, whether it's hiking, biking, or discovering new outdoor areas. I also take pleasure in making art, reading, cooking, and experimenting with new recipes from time to time. Staying active and involved in pursuits that bring me joy is essential for grounding myself as I continue my research.

How come you choose this field of science?
I selected this area of science because I have long been captivated by the relationship between our gut, our diet, and our overall health. The concept that the microbes residing in our bodies can impact not only digestion but also other organs, such as the lungs, piqued my interest. I aimed to investigate how these unseen processes contribute to conditions like Type 2 diabetes and respiratory problems, aspiring to enhance treatment options and deepen our understanding of bodily functions through my research.

What would you like to achieve with your science - for yourself and/or others?
On a personal level, I seek to deepen my expertise in this area while striving to develop improved treatments and preventive measures for conditions such as Type 2 diabetes-related neurological disorders and respiratory illnesses. Ultimately, my goal is to create a positive impact on public health and elevate the quality of life for individuals facing these health challenges.

Our research group wants to reach out to the general public with our research. Please, explain your research to someone who is not familiar with science.
I’m studying how a metabolites produced by bacteria in our gut, called imidazole propionate, affects the lungs. By feeding the mice different diets, I’m looking to see if this substance harms lung function and causes negative effects, which could help us understand its role in health problems like respiratory diseases in humans in the future.

 

And if you could explain one fascinating fact about your research to a child, what would it be?
Picture tiny helpers in your body known as microbes, similar to little bugs, that reside in your stomach. These small allies can influence your well-being, either promoting health or causing illness. My research is akin to a treasure hunt, as I seek to understand how these tiny organisms might also impact your lungs and whether they can enhance or hinder their function. It's like discovering how invisible superheroes or villains within us can alter our breathing!

What do you do to promote a healthy gut microbiome and/or health in general?
To encourage a healthy gut microbiome and overall wellness, I prioritize a balanced diet that includes plenty of fiber, fermented foods, and a wide range of plant-based options to nurture diverse gut bacteria. I also ensure I remain active by engaging in regular exercise, as physical activity significantly benefits gut health. Moreover, I focus on stress management, adequate sleep, and staying well-hydrated, all of which are essential for maintaining a healthy microbiome and promoting overall well-being.

 

What's one lab tool or technique you couldn’t live without?
A lab tool that I find indispensable is the microscope. It plays a vital role in analyzing tissue samples and gaining insights into the impact of different treatments at the cellular level. Whether I’m examining lung tissue histology or exploring microbial interactions, the microscope offers an insightful glimpse into the microscopic realm that influences many of my research endeavors. Without it, I would overlook essential details that are crucial for comprehending the inner workings of the body.

What advice would you give to someone just starting out in research?
I encourage you to remain curious and patient. Research can be tough, and outcomes may not always align with your plans, but perseverance is crucial. View setbacks as opportunities for growth, and don’t hesitate to ask questions or seek assistance from others, working together and learning from peers are vital aspects of the journey. Additionally, maintain an open mind and be adaptable, as science can take you to surprising yet intriguing directions. Lastly, remember to balance dedication with self-care, as taking care of your well-being is essential for sustained success.

If you could change one thing about the way people understand science, what would it be?
If I could alter one aspect of how people perceive science, it would be to emphasize that science is a process rather than merely a compilation of facts. Many individuals view science as a collection of definitive answers, but the reality is that it is an ever-evolving adventure of exploration, where each question gives rise to further inquiries and solutions often introduce new challenges. I wish more people would recognize science as a continuous voyage that demands curiosity, adaptability, and an openness to change in response to new evidence. This perspective could make science feel more approachable and significant to everyone.

Finally, if you could collaborate with any scientist, past or present, who would it be and why?
If I had the chance to collaborate with any scientist, whether from the past or present, it would be John Cryan. His groundbreaking research on the gut-brain axis and the microbiome's impact on health and disease has greatly inspired me. I think his deep knowledge of the relationship between the gut microbiome and overall health aligns seamlessly with my research interests. Working together would provide a remarkable opportunity to deepen our understanding of how microbes affect metabolic and neurological processes.

 

Thanks Avee for you contributions to the group!